Table 2. Combined effect of on-treatment control below the cut-off level of LDL cholesterol and CRP on recurrent stroke and TIA.

Group	N	Incidence Rate (100 persons/year)	Crude HR (95% CI)	P value	Overall P value	Adjusted HR	p value	Overall p value
LDL cholesterol ≥ 120 mg/dL, CRP ≥ 1 mg/L	171	4.19	1		0.032	1		0.019
LDL cholesterol < 120 mg/dL, CRP ≥ 1 mg/L	174	2.67	0.64	0.118		0.51	0.099
			(0.37, 1.12)			(0.23, 1.14)
LDL cholesterol ≥ 120 mg/dL, CRP < 1 mg/L	315	2.59	0.63	0.06		0.59	0.012
			(0.39, 1.02)			(0.39, 0.89)
LDL cholesterol < 120 mg/dL, CRP < 1 mg/L	417	2.02	0.49	0.003		0.41	0.006
			(0.31, 0.79)			(0.22, 0.78
Interaction with LDL cholesterol and CRP				0.601			0.51

Hazard ration (HR) was expressed using the LDL cholesterol ≥ 120 mg/dL and CRP ≥ 1 mg/L as the reference group. HR was estimated using proportional hazards regression models with frailty models clustered by stroke subtypes, high blood pressure, diabetes and statin use, and adjusted by age, sex, BMI, TC, HDL-C, TG, hypertension, FBS, chronic kidney disease creatinine and smoking as covariate. LDL: low density lipoprotein, CRP: C-reactive protein, CI: confidence interval.