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. 2019 May 7;10:475. doi: 10.3389/fphar.2019.00475

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Copyright © 2019 Wang, Xu, Fu, Lu, Guo, Wu, Sun, Liu, Yu and Sui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effectsof PPD on Ang II enhanced lung metastasis in vivo. (A) Schema of experimental protocol. Nude mice were vein intravenously injected with Ang II-pretreated A549 cells. Subsequently, nude mice were orally administered with the indicated doses of PPD for four consecutive weeks. (B) After injection at weeks 1 and 4, the mice were intraperitoneally injected with D-Luciferin for in vivo bioluminescence imaging. Tumor metastasis to lungs is shown. (C) Mean bioluminescence/time of lung metastasis in xenografted mice, graphed as normalized photon flux/time. (D) Mean bioluminescence at 4 weeks. (E) Representative images of lung metastatic nodules (arrows refer to tumor lesions). (F) Representative pictures of HE staining of the lung issue are shown (magnification, left × 100 and right × 400). *p < 0.05.