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. 2019 May 7;9:343. doi: 10.3389/fonc.2019.00343

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Copyright © 2019 Ferrata, Schad, Zimmer, Musholt, Bahr, Kuenzel, Becker, Springer, Roth, Weber and Fottner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microphotographs of representative examples of IHC PD-L1 expression in NEN G3 samples; different levels of staining (brown) are shown. (A) PD-L1 positive TC (score 1+) (gastrinoma, distant metastasis), (B) PD-L1 positive IC (score 1+) and PD-L1 negative TC (Merkel cell carcinoma lymph node metastasis), (C) PDL1 positive TC and IC, both score 1+ (lung, primary tumor sample), (D) PD-L1 positive TC (score 3+) (colon MiNEN, distant metastasis). PD-L1: programmed cell death ligand 1, IHC: immunohistochemistry, TC: tumor cells, IC: tumor-infiltrating immune cells, MiNEN: mixed neuroendocrine-nonneuroendocrine neoplasm.