Table 2.
Multivariable odds ratios and 95% confidence intervals for the relationship between reproductive and hormonal factors and lung cancer in the hospital-based lung cancer case-control study, 2009–2012.
| Cases | Controls | Age & CAS adjusteda | |
|---|---|---|---|
| N | N | OR (95% CI) | |
| Menstrual durationb (years) | 213 | 142 | 0.93 (0.88, 0.98) |
| Still menstruating | |||
| Yes | 25 | 71 | 0.41 (0.20, 0.85) |
| No | 196 | 114 | 1 (referent) |
| Age at menarche (years) | |||
| <14 | 46 | 50 | 0.93 (0.53, 1.62) |
| 14 | 58 | 62 | 0.88 (0.52,1.49) |
| ≥15 | 134 | 101 | 1 (referent) |
| p-trenda | 0.77 | ||
| Age at menopause b(years) | |||
| <45 | 61 | 39 | 2.14 (1.09, 4.17) |
| 45–49 | 98 | 55 | 1.93 (1.07, 3.51) |
| ≥50 | 71 | 52 | 1 (referent) |
| p-trenda | 0.02 | ||
| Number of pregnancies (gravidity) | |||
| ≤ 2 | 40 | 43 | 0.87 (0.48, 1.57) |
| 3–5 | 116 | 121 | 1 (referent) |
| >5 | 111 | 62 | 1.27 (0.78, 2.08) |
| p-trenda | 0.21 | ||
| Age at first live-birth (years) | |||
| Never pregnant | 15 | 10 | 1.07 (0.38, 3.00) |
| <18 | 50 | 47 | 0.80 (0.44, 1.44) |
| 18–20 | 98 | 80 | 1 (referent) |
| ≥21 | 79 | 69 | 0.76 (0.45, 1.28) |
| p-trenda | 0.76 | ||
| Birth control use | |||
| Ever | 29 | 39 | 0.79 (0.42, 1.50) |
| Never | 227 | 177 | 1 (referent) |
CAS, Cumulative Active Smoking; N, number of participants; OR, odds ratio; CI, confidence interval.
a
Estimates were adjusted for age and cumulative active smoking years; one subject with missing cumulative active smoking history was excluded.
b
Premenopausal women not included.
Unknown categories were retained in all models but not presented here.