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. 2019 May 7;10:538. doi: 10.3389/fphys.2019.00538

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Copyright © 2019 Cseh, Fabian, Quintana-Cabrera, Szabo, Eros, Soriano, Gallyas, Scorrano and Sumegi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PJ34 in combination with cisplatin or temozolomide on cytotoxicity and colony formation in B16F10 melanoma cells. Cells were treated as indicated in the figure, labeled with Annexin V^FITC (AV) and propidium iodide (PI) and subjected to flow cytometry. AV and PI double-negative live (A–D) as well as AV positive apoptotic cells (E–H) are presented as % of all cells after 4 (A,E), 24 (B,F), 48 (C,G), and 72 (D,H) hours of treatment. In a parallel experiment, B16F10 cells were treated as indicated in the figure and stained with trypan blue after 10 days of incubation. Representative image (I) and quantitative assessment (J) of colony formation is presented. Values are expressed as mean + SEM, N = 3, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001; NS, non-significant.