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. 2019 May 7;10:538. doi: 10.3389/fphys.2019.00538

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Copyright © 2019 Cseh, Fabian, Quintana-Cabrera, Szabo, Eros, Soriano, Gallyas, Scorrano and Sumegi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PARP^DN, cisplatin and temozolomide on mitochondrial fragmentation. B16F10 cells were co-transfected with either mtRFP and an empty vector (EV) (A,C) or mtRFP and pPARPGFPC1/N3 (B,C), treated as indicated in the figure for 4 h and the lengths of mitochondria were quantified. Panel (A,B) show representative reconstructions of confocal z-stacks while (C) displays the quantification of the mean length of mitochondria at 4-h post-treatments. Values are expressed as mean + SEM, N = 3, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. Scale bar: 10 μm.