Figure 7.

Forskolin‐evoked cAMP promotion of caffeine‐ and carbachol‐evoked Ca²⁺‐mediated anion secretion, but not vice versa. (a) Representative time courses and summary data showing the effect of low dose forskolin (For; 0.15 μM) or caffeine (Caf; 0.67 mM) addition alone, or the synergistic effect of the same dose of forskolin followed by caffeine in duodenal epithelial anion secretion (n = 5). (b) Representative time courses and summary data showing the effect of low dose forskolin (0.15 μM) or carbachol (30 μM) addition alone, or the synergistic effect of the same dose of forskolin followed by carbachol (n = 5). (c–d) Representative time courses and summary data showing the effect of low dose caffeine (0.67 mM), carbachol (CCh; 30 μM), or forskolin (0.15 μM) addition alone, or same dose caffeine or carbachol addition followed by forskolin (n = 5). ^* P < 0.05, significantly different from the corresponding control, ns: no significant differences