Figure 9.

A schematic representation of HIF‐1α‐dependent and ‐independent regulation of the post‐translation modulation of PP2A and PP2A activity in human aortic smooth muscle cells and ventricular cardiomyocytes exposed to hypoxia (24 hr). Solid lines show experimental findings while dashed lines are inferred consequences; red and blue signify inhibition and activation respectively. CIP2A, cancerous inhibitor of PP2A; DMOG, dimethyloxalylglycine; HIF‐1α hypoxia inducible factor 1α LCMT‐1, leucine carboxyl methyltransferase 1; PDH, prolyl‐4‐hydroxylase enzyme; PP2Ac, Protein phosphatase 2A catalytic subunit A; PME‐1, protein phosphatase methylesterase‐1