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. 2019 May 9;21(6):615–626. doi: 10.1016/j.neo.2019.04.004

Figure 2.

Figure 2

OMI of drug response heterogeneity in vivo. (A) Representative images of the redox ratio, NAD(P)H mean lifetime (τm), and FAD τm in vivo in PyVmT tumors treated with vehicle or paclitaxel + XL147 (P + X) for 48 hours. Scale bar = 100 μm. (B) OMI Index quantified at the single-cell level 48 hours after treatment in vivo for each tumor. Each dot represents one cell. A decrease in the OMI index indicates drug response. Error bars indicate mean ± SD. N > 450 cells/tumor. (C) Decrease in average OMI Index with treatment across all cells from all tumors. Error bars indicate mean ± SD. * P < .0001 vs. vehicle. N > 3300 cells/group. (D) Population density distributions of drug response at the single-cell level for each tumor. (E) The effect of treatment on the degree of OMI Index heterogeneity per tumor quantified by the wH-index. Error bars indicate mean ± SD. N = 1000 fits/tumor. Each dot represents one tumor. *P < .05 vs. vehicle.