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. 2015 Oct 20;142(20):3583–3591. doi: 10.1242/dev.125872

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© 2015. Published by The Company of Biologists Ltd

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Fig. 5. — Visualizing heart developmental events using the 4D atlas. (A-D) From the 4D atlas, three slices showing average heart development at E11.50 (A), E12.75 (B) and E13.70 (C) are shown. Formation of the chambers (la, left atrium; lv, left ventricle; ra, right atrium; rv, right ventricle) is clearly visible. The bulbar ventricular canal (bvc), which is open at E11.50 (A), is becoming closed by the interventricular septum (ivs) at E12.75 (B) and is fully closed at E13.70 (C). Cardiac trabeculation, which does not follow stereotypical patterning, is blurred out in the average image (C), but is evident in the equivalent slice of any single individual embryo at E13.70 (D).