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Absence of LGN and Gαi function leads to profound deafness. Auditory brainstem response thresholds for constitutive Lgn mutants (Lgn DEL/DEL) (A) and Gαi inactivation in post-mitotic HCs (Atoh1-Cre; PTXa) (B). LgnDEL/DEL (n=6) and LgnDEL/+ control littermates (n=8), Atoh1-Cre; PTXa (n=8) and 0; PTXa (n=10) control littermates (without the Atoh1-Cre transgene) were tested once at P21-P25 (mean±s.d.).
