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. 2018 Mar 15;145(6):dev156612. doi: 10.1242/dev.156612

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© 2018. Published by The Company of Biologists Ltd

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Fig. 4. — Partial deficiency of Nanos2 promotes teratoma-susceptible phenotypes in tumor-resistant germ cells. (A-F) Oct4ΔPE::GFP transgenic E14.5 or E15.5 B6-Nanos2^+/+ and B6-Nanos2^KO/+ testes were sectioned and immunostained for (A,B) DNMT3L, (C,D) CCND1 and (E,F) Nanog. (A,C,E) Oct4ΔPE::GFP-positive germ cells, which are positive and negative for DNMT3L, CCND1 or NANOG, were counted. Data are plotted as the average percentage of germ cells positive for (A) DNMT3L, (C) CCND1 or (E) NANOG ±s.e.m. (n=5-9). *P<0.05; ^†P<0.01; ^#P<0.0001. (B,D,F) Representative confocal microscopy images of E14.5 or E15.5 Oct4ΔPE::GFP transgenic B6-Nanos2^+/+ and B6-Nanos2^KO/+ gonads immunostained for (B) DNMT3L, (D) CCND1 or (F) NANOG. Small groups of DNMT3L-, CCND1- or NANOG-positive germ cells are indicated (arrowheads). Scale bars: 50 μm.