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. 2018 Mar 15;145(6):dev156612. doi: 10.1242/dev.156612

Fig. 6.

Fig. 6.

OTX2 expression associates with aberrant germ cell proliferation. Oct4ΔPE::GFP transgenic E15.5 M19 testes were sectioned and immunostained for OTX2 and KI67. Oct4ΔPE::GFP-positive germ cells, single positive for OTX2 or KI67, and double positive for both OTX2 and KI67 were counted. (A) Data are plotted as the average percentage of OTX2-positive and -negative germ cells positive for KI67 ±s.e.m. (n=4). (B) Confocal microscopy images of E15.5 Oct4ΔPE::GFP transgenic M19 gonads immunostained for OTX2 and KI67. KI67-positive, OTX2-positive germ cells (white outlines) and KI67-positive, OTX2-negative germ cells (yellow outlines) are indicated. Scale bar: 50 μm.