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. 2019 May 7;13:186. doi: 10.3389/fncel.2019.00186

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Copyright © 2019 Holman, Poppi, Frerck and Rabbitt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Expression of the reporter tdT (red) was found primarily in a subset of extrastriolar cells in the utricle and saccule at the earliest time point examined, postnatal day 1 (P1). Images are maximum intensity projections (MIPs) from 70μm z-stacks through excised tissues. The striola in both the utricle and saccule are outlined with dotted lines. (B) Cells expressing tdT (red) at P1 immunolabeled with an antibody against ATOH1 (blue) and were identified as immature hair cells (HCs), while supporting cells (SCs) immunolabeled with an antibody against SOX2 (green). (C) By age P15, tdT (red) expressing cells immunolabeled with myosin VIIa (blue), with a few tdT negative hair cells immunolabeled with the SOX2 antibody (green). (D,E) Cells expressing tdT (red) had a flask-shaped morphology (arrows) and maintained their extrastriolar location within the utricle in adults (D: P78) and geriatric ages (E: P533).