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. 2019 May 10;6(2):ENEURO.0334-18.2019. doi: 10.1523/ENEURO.0334-18.2019

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Copyright © 2019 Narla et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — CRF mediates the phase/amplitude coupling during stressor. A, upper traces, Examples of fast ripple activity and θ band in control, CP 154526, and after 24-h drug wash out from TBI rats under stress filtered into θ (3–8 Hz, blue) and fast ripples (250–500 Hz, red) bands. B, Comparison of MIs between low-frequency phase on x-axis and higher frequency amplitude between 250 and 500 Hz on y-axis. Fast ripples (>250 Hz) are significantly and highly coupled over the frequency bins corresponding to θ rhythm. Ripple activity is also coupled to a lesser extent in the same range. This relationship is abolished by CRFR₁ antagonism. Very low-frequency activity (2–4 Hz) is apparently coupled over a wide range of high-frequency activity. The MI values corresponding to this coupling during antagonist are below chance. After 24 h, the PAC returned.