Table 3.

Pharmacokinetic parameters of Erinacine S in rat plasma after oral administration of H. erinaceus mycelia extract at 2.395 g/kg body weight (equivalent to 50 mg/kg body weight of Erinacine S) and intravenous administration of Erinacine S at 5 mg/kg.

	P.O.	I.V.
	(50 mg/kg)	(5 mg/kg)
Tmax (min)	270.00 ± 73.48	-
Cmax (μg/mL)	0.73 ± 0.31	1.64 ± 0.17
T1/2 (min)	439.84 ± 60.98	11.45 ± 5.76
AUC (min μg/mL)	272.06 ±77.82	179.77 ± 66.46
Absolute Bioavailability (%)	15.13

Data expressed as mean ± SD (n = 6). T_max—the time taken to reach the maximum concentration. C_max—maximum plasma concentration. T_1/2—half-life. AUC—area under the plasma concentration-time curve. Absolute bioavailability (%) = [(AUCpo × Doseiv)/(AUCiv × Dosepo)] × 100%. po—oral administration; iv—intravenous administration.