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. 2019 Apr 19;24(8):1556. doi: 10.3390/molecules24081556

Figure 7.

Figure 7

Effects of the ethyl acetate fraction of AHE on the DES/MPA-induced uterine leiomyoma in mice. (A) Diagram of the uterine leiomyoma mice model via DES and MPA induction. Female (5–6 weeks old) ICR mice were treated with DES (0.4 mg/kg) by oral gavage once daily for 4 weeks. After DES treatment for 4 weeks, mice were cotreated with DES and MPA (5 mg/kg) for an additional 4 weeks. At the 7th week of DES/MPA treatment, mice were treated with or without the ethyl acetate fraction of AHE (0.4 and 2 g/kg) and/or stigmasterol (0.2 and 1 mg/kg) by oral gavage once daily for 2 weeks. After sacrifice, the serum levels of (B) E2 and (C) P4 were measured using ELISA. The uteri were harvested and (D) photographed and weighted. (E) The weights of uteri were (F) normalized to the body weights. Data represent means ± SEM (n = 5). * p < 0.05, ** p < 0.01 compared with the control group. # p < 0.05, ## p < 0.01 compared with the MC group. Scale bar = 1 cm. C, control. MC, model control. STL, stigmasterol.