Figure 3.

Evolution of aeRF-1 superfamily with known domain architectures and conserved gene neighborhoods. (A) Collapsed phylogenetic tree depicting relationships within the aeRF-1. (B–I) Notable domain architectures and conserved gene neighborhoods grouped according to clades. Individual domains of any given single protein architecture are depicted as discrete, colored shapes. In (F), individual genes in conserved gene neighborhoods are depicted as boxed arrows with the arrowhead pointing in the 3′ direction. Genes with multiple domains have their boxes split into distinct colors, one color for each discrete domain. Domain abbreviations: VTC, Vms1 Treble Clef; ZnR, zinc ribbon; 2βs, 2-β-strand insert domain; SBDS, Shwachman-Bodian-Diamond syndrome; N, distinctive N-terminal extension shared between certain families of the VLRF-1 clade.