Figure 1.

SR141716A ameliorates DIO phenotype by inducing weight loss. DIO was induced in mice by 12 weeks of purified diet feeding. After week 12, mice were treated orally with either SR (10 mg/kg/day) or Veh (0.1% Tween 80) for 4 weeks. A, experimental timeline. B, experimental groups and description of purified diet. C, daily body weight of each group of mice is shown for the duration of treatment. D, weekly energy intake during the 4-week intervention. For C and D, n = 9–10. Data are shown as mean ± S.D. (error bars). Data were analyzed using two-way ANOVA with a Tukey post hoc test. p < 0.05 if alphabetical characters differ between the groups being compared.