Figure 4.

IL-6 treatment stimulates bone formation in vivo but requires the addition of sIL-6R. A, schematic diagram. B, calvarial thickness in 6-week-old male C57BL/6 mice with vehicle (saline), hIL-6 alone (0.2 μg/day), hIL-6 (0.2 μg/day) with sIL-6rα (0.1 μg/day), hyper-IL-6 (0.2 μg/day), or murine OSM (0.2 μg/day) by subcutaneous calvarial injections. Data are shown as individual data points for each animal with mean ± S.E. (error bars); *, p < 0.01, p < 0.001 versus vehicle by one-way ANOVA with Sidak post hoc test.