Figure 6.

Male and female PEPCK-sgp130-Fc mice demonstrate impaired growth and low trabecular bone mass at high levels of sgp130-Fc. A, serum human gp130 levels at 12 weeks of age used to segregate mice into sgp130-Fc^low (gp130 < 10 μg/ml) and sgp130-Fc^high (gp130 > 10 μg/ml) groups. Shown are total body weight (B) and femoral length (C) at 12 weeks of age in male and female sgp130-Fc^low and sgp130-Fc^high mice. D, representative images of the trabecular region, showing reduced trabecular bone mass in both male and female sgp130-Fc^high mice. Scale bar, 500 μm. E–G, quantification of trabecular structure in 12-week-old male and female sgp130-Fc^low and sgp130-Fc^high mice. Data are shown as individual data points and means with S.E. (error bars) for each group; n = 5–12/group. *, p < 0.05; **, p < 0.01 for comparison with WT mice of the same sex and age by two-way ANOVA.