Figure 7.
Male and female PEPCK-sgp130-Fc mice have narrower cortical bone at high levels of sgp130-Fc. Caliper measurements of mid-diaphyseal femoral mediolateral and anteroposterior widths (A and B), and quantitative micro-CT data for femoral periosteal perimeter, cortical thickness, moment of inertia, and marrow area (C–F) in 12-week-old male and female sgp130-Fclow and sgp130-Fchigh mice; data shown as individual data points and means with S.E. (error bars) for each group; n = 5–12/group. *, p < 0.05; **, p < 0.01; ***, p < 0.001 for comparison with WT mice of the same sex and age by two-way ANOVA.