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. 2019 Apr 1;294(19):7537–7545. doi: 10.1074/jbc.REV119.006348

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© 2019 Dinman.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — The scaling relationship between recoding efficiency and signal output is not linear in eukaryotic cells. A, examples showing the relationship between PRF efficiency and mRNA abundance. a, in the absence of PRF, the input is equal to output, with an assigned value of 1. b, if a −1 PRF event occurs within an ORF with a frequency of 10%, the amount of functional protein product synthesized is ∼0.6. c, in the case where production of the functional protein requires a −1 PRF event, if this occurs with a frequency of 10%, the total output is not 0.1, but rather ∼0.01. d, inactivation of nonsense-mediated mRNA decay (orange triangle) can boost signal output to ∼0.9 in orientation b. B, empirically determined relationship between −1 PRF efficiency and mRNA abundance (35).