Figure 7.

GRP78 is expressed at the plasma membrane in type I diabetic Akita mice. Kidneys were harvested from WT or Akita mice at 30 weeks of age (n = 3/group). A, paraffin-embedded sections were stained for GRP78. Black arrows indicate areas in which GRP78 appears to be localized to the plasma membrane. B, OCT sections were stained for GRP78 (red) or the plasma membrane marker α8-integrin (green). Areas of colocalization between GRP78 and the plasma membrane are indicated by white in the overlay and mask images.