Figure 6.

Lectin-releasing microgels fabricated from glycopeptide nanofibers. (a) Schematic representation of microgels fabricated from self-assembled peptide nanofibers via desolvation. (b) Microgels ranging from 5–12.5 µm in diameter can be fabricated by adjusting peptide concentration in solution. (c) WGA burst release curves from microgels with different GlcNAc content: 0% (circles), 5% (squares), 10% (triangles), or 25% (diamonds). Burst release decreased with increasing amount of GlcNAc-Q11. (d) Jurkat apoptosis induced by WGA released from Q11 microgels (gray), or stock WGA that was not subjected to desolvation (black), demonstrating that the released proteins were active. “ns” denotes p > 0.05 between indicated groups, **** indicates p < 0.001, ANOVA with Tukey’s post hoc. Adapted from reference [100] with permission from The Royal Society of Chemistry.