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. 2019 Apr 22;20(8):1958. doi: 10.3390/ijms20081958

Figure 2.

Figure 2

Differentially expressed genes and microRNAs with potential microRNA–target gene interactions identified in idiopathic pulmonary fibrosis (IPF) fibroblasts treated with epigallocatechin gallate (EGCG). A total of (a) 61 differentially expressed genes and (c) 56 differentially expressed microRNAs were identified in the EGCG-treated IPF fibroblasts with next-generation sequencing methods, and the heatmaps according to z-scores are illustrated. (b) Using the miRmap database for microRNA target prediction (selection criteria of miRmap score ≥97.0), 942 putative targets of the 22 upregulated microRNAs and 1334 putative targets of the 34 downregulated microRNAs were identified. Matching to the 16 downregulated genes and 45 upregulated genes identified in the EGCG-treated IPF fibroblasts, the intersection Venn diagram identified five potential microRNA–mRNA interactions (as shown in Table 1).