Table 3.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the significantly differentially expressed genes in idiopathic pulmonary fibrosis (IPF) fibroblasts treated with epigallocatechin gallate (EGCG).
| Description | Count | p-value | Adjusted p-value * |
Genes | Fold Enrichment |
|---|---|---|---|---|---|
| Steroid biosynthesis | 10 | 2.11 × 10−16 | 1.42 × 10−14 | SC5D, MSMO1, SQLE, CYP51A1, DHCR7, LSS, HSD17B7, NSDHL, FDFT1, DHCR24 | 90.51 |
| Biosynthesis of antibiotics | 14 | 2.91 × 10−11 | 9.31 × 10−10 | SC5D, MSMO1, MVD, CYP51A1, SQLE, HMGCR, FDPS, HMGCS1, LSS, IDI1, ACSS2, HSD17B7, NSDHL, FDFT1 | 11.95 |
| Terpenoid backbone biosynthesis | 5 | 4.84 × 10−6 | 1.03 × 10−4 | MVD, HMGCR, FDPS, HMGCS1, IDI1 | 41.14 |
| Metabolic pathways | 19 | 1.53 × 10−5 | 2.45 × 10−4 | SC5D, MSMO1, MVD, CYP51A1, HMGCR, HMGCS1, FDPS, LSS, ACSS2, FDFT1, SQLE, DHCR7, QPRT, PLA2G3, ITPK1, IDI1, HSD17B7, NSDHL, DHCR24 | 2.82 |
* p-values adjusted with false discovery rate using the method by Benjamini et al.