AMPK	AMP-activated protein kinase
ANOVA	Analysis of variance
COMB	Combination group
CTRL	Placebo group
FDA	Food and Drug Administration
FLU	Fluvastatin group
FMD	Flow mediated dilation
hTERT	human telomerase reverse transcriptase
MILES	Metformin in Longevity Study
mTOR	Mechanistic target of rapamycin
NAD	Nicotinamide adenine dinucleotide
NF-κB1	Nuclear factor κB
NFE2L2	Nuclear factor (erythroid-derived 2)-like 2 gene
PRKAA	5′-AMP-activated protein kinase catalytic subunit α-2 gene
PWV	Pulse wave velocity
qPCR	Quantitative real-time polymerase chain reaction
SIRT1	Sirtuin 1 gene
VAL	Valsartan group