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. 2019 Apr 24;20(8):2014. doi: 10.3390/ijms20082014
MPS Mucopolysaccharidosis
MPSII Mucopolysaccharidosis type II
IDS Iduronate 2-sulfatase
NPs nanoparticles
g7 Gly-L-Phe-D-Thr-Gly-L-Phe-L-Leu-L-Ser(O-β-D-Glucose)-CONH2
g7-NPs Brain targeted NPs
g7-NPs-IDS g7-NPs loaded with IDS enzyme
LSDs Lysosomal storage disorders
GAG Glycosaminoglycan
ERT Enzyme replacement therapy
BBB Blood-brain barrier
CNS Central nervous system
PLGA Poly(D,L-lactide-co-glycolide)
Ids-ko Ids knockout
Wt Wild-type
UT Untreated
PVA Polyvinyl alcohol
PBS Phosphate buffer saline
FBS Fetal bovine serum
NBT/BCIP nitro-blue tetrazolium chloride/5-bromo-4-chloro-3′-indolyphosphate p-toluidine salt