Table 4.
Genotype and allele distribution of single-nucleotide polymorphisms among the four genes in COPD patients and response to ICS according to 6MWD. Δ > 50 m = responders, Δ < 30 m = non-responders.
| SNP | Responders Patients Number (% Over Total) | Non-Responders Patients Number (% Over Total) | % Responders Genotype | p * |
|---|---|---|---|---|
| rs37972 | ||||
| CC | 22 (32.35%) | 8 (11.77%) | 73.3% | 0.08 |
| CT | 21(30.88%) | 12 (17.65%) | 62.6% | |
| TT | 5 (7.35%) | 0 | 100% | |
| rs4713916 | ||||
| GG | 37 (55.22%) | 19 (28.36%) | 60% | 0.039 |
| GA | 10 (14.92%) | 1 (1.5%) | 90.91% | |
| rs6189 | ||||
| GG | 45 (67.16%) | 19 (28.35%) | 70.31% | NS |
| GA | 3 (4.48%) | 0 | 100% | |
| rs6190 | ||||
| GG | 44 (65.67%) | 20 (29.85%) | 68.75% | NS |
| GA | 3 (4.48%) | 0 | 100% | |
| rs41423247 | ||||
| CC | 4 (5.88%) | 3 (4.41%) | 57.14% | NS |
| GC | 19 (27.94%) | 7 (10.29%) | 73.07% | |
| GG | 25 (36.76%) | 10 (14.71%) | 71.42% | |
| rs2032582 | ||||
| GG | 14 (20.59%) | 10 (14.71%) | 58.33% | NS |
| GA | 3 (4.41%) | 0 | 100% | |
| GT | 15 (22.06%) | 6 (8.82%) | 71.43% | |
| TT | 16 (23.53%) | 4 (5.88%) | 80% |
* According to Mann–Whitney test.