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. 2019 Apr 16;24(8):1498. doi: 10.3390/molecules24081498

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of treatment with melittin (MEL) on the B-cell lymphoma-2 (Bcl-2) protein level in lung tissues. A: Representative lung immunohistochemical graphs (a: control group, b: paraquat (PQ) group, c: PQ + MEL (0.1 mg/kg) group, d: PQ + MEL (0.5 mg/kg) group); (a) showed a noticeable expression of bcl-2 immunostaining in the alveolar lining epithelium (arrow). (b) presented marked decrease in bcl-2 expression within the alveolar lining epithelium (arrow). (c) displayed mild to moderate increase of bcl-2 expression in the alveolar epithelium (arrow). (d) illustrated an obvious increase in bcl-2 expression within the alveolar epithelium (arrow). Magnification = X200 and scale bar = 100 µm. B: Statistical analysis of Bcl-2 H-score. Data are expressed as mean ±SD. Significantly (** p < 0.01) different to the PQ group.