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. 2019 Apr 16;24(8):1498. doi: 10.3390/molecules24081498

Figure 9.

Figure 9

Effect of treatment with melittin (MEL) on Ki-67 protein level in lung tissues. A: Representative lung immunohistochemical graphs (a: control group, b: paraquat (PQ) group, c: PQ + MEL (0.1 mg/kg) group, d: PQ + MEL (0.5 mg/kg) group); (a) showed mild expression of Ki-67 immunostaining within the alveolar and bronchial lining epithelium (arrow). (b) presented an obvious increase in the inter-alveolar septa (arrow) as well as in the necrotic epithelial bronchial lining (arrowhead). (c) illustrated a marked decrease in Ki-67 expression within the alveolar and bronchial epithelium (arrowhead). (d) indicated a noticeable decline in Ki-67 expression within the alveolar and bronchial epithelium (arrowhead). Magnification = X200 and scale bar = 100 µm. B: Statistical analysis of Ki-67 H-score. Data are expressed as mean ±SD. Significantly (* p < 0.05, ** p < 0.01, *** p < 0.001) different from the PQ group.