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. 2019 Apr 20;20(8):1943. doi: 10.3390/ijms20081943

Figure 4.

Figure 4

Comparison of the structures of the DDE triad (Asp, Asp, and Glu) and its vicinities. (A) Superimposed DDE triad region non-cryogenic (green) and cryogenic (blue) structures of HIV-1 integrase catalytic core domain. (B) Hydrogen bond network mediated by water molecules near the active site.