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. 2019 Apr 24;20(8):2026. doi: 10.3390/ijms20082026

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic diagram that outlines phosphoinositide 3 kinase (PI3K) signaling from pluripotency maintenance to differentiation in human stem cells. Green arrows represent activation, red represent inhibition. FGFR, fibroblast growth factor receptor; IGF1R, insulin-like growth factor 1 receptor; OPN, osteopontin.