Figure 8.

Calcr contributes to body temperature regulation during the night (the active phase for mice). Mouse BTR (A) and locomotor activity rhythm (B) in control (Calcr^+/+: blue line) and Calcr knockout (Calcr^−/−: orange line) mice. The body temperatures of wild-type mice showed a deep trough at midnight, whereas the body temperatures of Calcr knockout mice lost the characteristic trough and remained relatively unchanged during the night (A). The locomotor activity rhythm in Calcr knockout did not show a significant difference from that of the control, suggesting that Calcr is responsible for mammalian body temperature regulation but not locomotor activity rhythm during the night (the active phase for mice). White and black bars on the graphs indicate the 12-h light and dark phases. The graphs are modified from Goda et al. 2018, Figure 6 [23]. *: p < 0.05, ***: p < 0.001.