Fig. 5.

Electrophysiological recordings of Purkinje cells in control and Foxp2-PCKO mice. a Example traces showing simple spikes and complex spikes (+) of Purkinje cells in Foxp2-PCKO (red) and control mice (black) in vivo. b Increased simple spike firing (right panel) but normal complex spike activity (left panel) in Foxp2-PCKO mice at rest. c Example traces with wheel motion velocity plotted in the upper panels. Transparent boxes in grey indicate epochs of reduced Purkinje cell activity in relation to pre-peak velocity in control mice, whereas boxes in red indicate increased activity at trough velocity in Foxp2-PCKO mice. d Foxp2-PCKO mice showed higher Purkinje cell activity (upper panel) and a lower maximum correlation coefficient between wheel velocity and simple spike response (lower panel) during spontaneous locomotion. e Foxp2-PCKO mice showed higher output of action potentials when injected with different currents in the Purkinje cell in vitro (control n = 11, 3 mice; Foxp2-PCKO n = 11, 2 mice). Error bars represent ± s.e.m