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. 2018 Dec 7;26(1):57–64. doi: 10.1038/s41434-018-0049-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Experimental design. Six weeks after lentiviral vector delivery, the animals were lesioned with an intrastriatal 6-OHDA lesion protocol. Behavior assessment was performed 7, 14, and 19 weeks after lesion. The animals were euthanized 19 weeks after lesion. One subgroup of LV-GDNF-F-DD animals was used to test if GDNF could rescue SNpc cells and motor behavior from a degenerating dopaminergic system (Rescue). Another subgroup of LV-GDNF-F-DD animals was used to test if GDNF could regenerate SNpc cells and motor behavior after the nigrostriatal system has degenerated (Regeneration). One subgroup of LV-GDNF-F-DD animals was not given any TMP (OFF) and used as control for DD leakiness. The LV-YFP-DD animals, and Rescue and Regeneration animals were given TMP continuously 1 week before 6-OHDA lesion and used as lesion control