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. 2018 Dec 7;26(1):57–64. doi: 10.1038/s41434-018-0049-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — GDNF-F-DD leads to partial recovery of motor impairment when there is an ongoing nigrostriatal degeneration. a Amphetamine-induced rotations measured 7, 14, and 19 weeks after 6-OHDA lesion (n = 8–10 per group). One-way ANOVA with Tukey multiple comparison tests performed on week 19. Repeated-measures ANOVA with Tukey multiple comparison tests performed on weeks 7, 14, and 19 was statistically significant in the Rescue group. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.0001. b Correlation between numbers of TH neurons and amphetamine-induced rotations on week 19. c Correlation between numbers of VMAT2 neurons and amphetamine-induced rotations on week 19. d Correlation between numbers of pRPS6 neurons and amphetamine-induced rotations on week 19