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The mRNA levels of PYY, GLP-1, and NTS under the addition of 5-azacytidine (5AZC), trichostatin A (TSA), and 5AZC+TSA. The addition of TSA only and 5AZC only attenuated the IH-induced up-regulation of PYY, GLP-1, and NTS. On the other hand, combined addition of TSA+5AZC recovered the IH-induced up-regulation of PYY, GLP-1, and NTS mRNA levels in Caco-2 cells. All data are expressed as the mean±SE for each group (n = 4–8). The statistical analyses were performed using Student’s t-test.
