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. 2019 Apr 30;2019:3019794. doi: 10.1155/2019/3019794

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Copyright © 2019 José Roberto Macías-Pérez et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Macroscopic and histological H&E staining observations of the effect of α/β-AR blockers and curcumin on CCl4-induced liver cirrhosis in hamster. Representative pictures of the healthy livers (intact group), the livers of animals with cirrhosis induced (cirrhotic group) and, after the cirrhosis, treated with water (placebo), doxazosin (D), carvedilol (Ca), curcumin (Cu), doxazosin and carvedilol (D+Ca), doxazosin and curcumin (D+Cu), carvedilol and curcumin (Ca+Cu), and the combination of doxazosin, carvedilol, and curcumin (D+Ca+Cu). The H&E staining shows in the cirrhotic group: steatosis (black arrow) and necrosis (asterisk); in the placebo group: ballooning (arrowhead) and necrosis (asterisk); and in the D and Ca groups: ballooning (arrowheads). Magnification, 20x.