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Bi-directional transport of difference chicken P-gp substrates across MDCK-chAbcb1 cell monolayer after pre-treatment with berberine for 2 h. (A) Tilmicosin. (B) Ciprofloxacin. (C) Clindamycin. (D) Sulfadiazine. (E) Ampicillin. (F) Enrofloxacin. Data are shown as mean ± SEM of three independent experiments. * p < 0.05; ** p < 0.01.
