Table 1.

Cell reprogramming factors in the tumorigenesis of breast cancer.

Reprogramming Factor	Action2	Target Cells	Consequence	Reference
PIK3CA	+	BC3, LC4	LC, BC, MaSC6, tumor	[34,35]
MYC	+	IMEC5, LC	BC, MaSC, tumor	[38]
ERBB2	+	LC	BC, MaSC, tumor	[39]
PyMT1	+	LC	BC, MaSC, tumor	[39]
SOX10	+	LC	BC, MaSC, NCC7	[50]
SOX9 + Slug	+	BC, LC	MaSC, EMT8	[19]
TP53	-	LC	BC, MaSC, tumor	[44–46]
BRCA1	-	LC	BC, tumor	[48]
FOXA1	-	LC	BC, tumor	[65]

¹ Polyoma virus middle T antigen; ² activation (+) or inactivation (-) during cell reprogramming; ³ basal-lineage cells; ⁴ luminal-lineage cells; ⁵ TERT-immortalized mammary epithelial cells; ⁶ mammary stem/progenitor cells; ⁷ neural crest cells; ⁸ epithelial to mesenchymal transition.