Skip to main content
. 2019 Apr 24;20(8):2010. doi: 10.3390/ijms20082010

Figure 2.

Figure 2

Negative regulation of the TRAIL-driven pathway. (A) OVAAL, a long non-coding RNA, has been shown to promote interaction between STK3 and Raf-1. STK3 and Raf-1 work synchronously and activate the MEK/ERK pathway; (B) ERK has also been shown to stabilize MCL-1. ERK is also activated by TRAF6 and GADD34 to stabilize MCL-1. OVAAL is transcriptionally upregulated by c-Myc; (C) Post-translational modifications have been shown to effectively regulate caspase-8 and FADD. FADD is negatively regulated by C terminus HSC70-interacting protein (CHIP); (D) Caspase-8 is negatively regulated by Cullin-7; (E) ITCH involved in the negative regulation of c-FLIP.