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Effects of compound 1 on mitochondrial swelling. (A): RLM (1 mg/mL) were incubated in a medium containing succ (5 mM) and rot (1.25 µM). (B,C): RLM (1 mg/mL) were incubated in a medium containing glu (5 mM) and mal (1 mM). Test compound was added at 1 μM (A,C) or at indicated concentrations (B). Ca2+ was present or added at 20 μM. Dotted line represents the behavior of mitochondrial swelling without the addition indicated by the arrow.
