Figure 4.

Effects of G75 on the biological pathways involved in wound healing. (A) Significantly activated biological processes on day three of G75 treatment based on the enriched GO clusters visualized by ClueGO are shown. To reduce redundancy of GO terms, fusion option was selected. For the functionally grouped networks with terms as nodes, the size of nodes represents the term enrichment significance linked with edge size based on their kappa score level (≥0.4), in which only the label of the most significant term per group is shown. (B) CTGF expression was increased by G75. Representative western blot analysis of CTGF expression in skin tissues collected from G75-treated mice three days after wounding. The results are presented as means ± S.E.M (n = 3). * p < 0.05, two-tailed Student’s t-test.