Scheme 3.
Preparation of triazole-containing peptides 4b and alkyne-labeled peptide 17. Reagents and Conditions: i) Ph(CH2)8N3 (16), CuI, l-ascorbic acid, DMF:BuOH:Pyr (3:5:2); ii) Cp*RuCl(PPh3)2, Ph(CH2)8N3 (16), DMF; iii) TFA:H2O:TIS (95:2.5:2.5).
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