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. 2019 Apr 16;24(8):1488. doi: 10.3390/molecules24081488

Table 1.

Inhibitory potencies of peptides containing different linkers using a fluorescence polarization (FP) assay. Polo-like kinase (Plk), polo-box domain (PBD).

graphic file with name molecules-24-01488-i001.jpg

Peptide R IC50 (nM)
PLK1 PBD PLK2 PBD PLK3 PBD
1 i graphic file with name molecules-24-01488-i002.jpg 650 ± 39 ND iv ND
17 graphic file with name molecules-24-01488-i003.jpg 1000 ± 140 ND ND
13 graphic file with name molecules-24-01488-i004.jpg 1100 ± 45 ND ND
2a ii graphic file with name molecules-24-01488-i005.jpg 15 ± 0.94 220 ± 15 1100 ± 230
2b iii graphic file with name molecules-24-01488-i006.jpg 15 ± 0.33 180 ± 14 450 ± 87
3a graphic file with name molecules-24-01488-i007.jpg 110 ± 6.6 ND ND
3b graphic file with name molecules-24-01488-i008.jpg 100 ± 19 ND ND
3c graphic file with name molecules-24-01488-i009.jpg 130 ± 9.8 ND ND
3d graphic file with name molecules-24-01488-i010.jpg 25 ± 1.6 5900 ± 420 9900 ± 2200
4b graphic file with name molecules-24-01488-i011.jpg 17 ± 0.17 690 ± 20 3400 ± 130

i See reference [14]; ii See reference [15]; iii See references [25,26]; iv Not determined.