Figure 1.

Intracellular signaling triggered by VEGF receptors. Specific transmembrane receptor tyrosine kinase for VEGF, i.e., VEGFR 1–3, recruit PLCγ, Src and FYN in order to signal mainly through DAG receptors (PKC), PKA, Rac1, MEK and Akt/mTOR. Transcription factors activated by these signaling, including NFAT or AP1, will finally regulate gene expression associated to VEGFR/VEGF binding. Increased levels of intracellular calcium also linked to this binding will contribute to PKC and NFAT activation, among others.