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Comparison of decellularized extracellular matrix (dECM) sources for cancer research.
| dECM Type | Advantages | Disadvantages |
|---|---|---|
| Tissue/organ-derived dECM | -Similar to native ECM composition and structure | -Limited ECM sources -Difficult for large-scale in vitro analyses -Large batch-to-batch differences due to cancer heterogeneity |
| Cultured cell-derived dECM | -Possible for large-scale in vitro analyses | -Difficult to prepare dECM that completely mimics native ECM composition and structure |
