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. 2019 Apr 16;20(8):1888. doi: 10.3390/ijms20081888

Figure 4.

Figure 4

Activation of SLC25A13 gene by FOXA2. (A) FOXA1, FOXA2 and FOXA3 mRNA levels in HepG2 and SK-N-SH cells. (B) HepG2 and SK-N-SH cells co-transfected with pGL3 basic-LUC vector containing C2 construct (968/−19 of the SLC25A13 gene promoter region) wild-type (W) or mutated (M) in FOXA2 binding site and with pcDNA3-FOXA2 (+: black bars) or empty pcDNA3 (-: white bar) were assayed for LUC activity. Where indicated, differences between samples and relative controls were significant (*p < 0.05 or **p < 0.01 one-way ANOVA followed by Student’s t-test).